Colleagues, hello! We encountered cases where there is no clear hereditary pathology, but there are persistent suspicions of a genetic predisposition - for example, cardiovascular, autoimmune, neurological. There are many panels, a ton of data, but it is not clear how to filter out the noise and look for significant options. Does anyone use a platform suitable for such multifactorial diagnoses?

Yes, these are exactly the tasks we turned to https://compassbioinfo.com/ . InheriNext® is very flexible: you can set filters manually, select gene panels, filter by frequency, by consequences, by sources. In multifactorial cases, this is important, because often there is not one pathogen, but a complex of factors. It is very helpful that each option is accompanied by an explanation and links to databases. This makes it possible not just to trust, but to understand.

Thank you for feedback! We often come across such "uncertain" cases, and regular automatic systems just produce noise. But if there is filtering, a link with the phenotype and the ability to manually configure - this is exactly what you need. I'll go try demo!